What Are the Signs and Symptoms of Cystic Fibrosis?

The signs and symptoms of cystic fibrosis (CF) vary from person to person and over time. Sometimes you’ll have few symptoms. Other times, your symptoms may become more severe.

One of the first signs of CF that parents may notice is that their baby’s skin tastes salty when kissed, or the baby doesn’t pass stool when first born.

Most of the other signs and symptoms of CF happen later. They’re related to how CF affects the respiratory, digestive, or reproductive systems of the body.

Figure A shows the organs that cystic fibrosis can affect. Figure B shows a cross-section of a normal airway. Figure C shows an airway with cystic fibrosis. The widened airway is blocked by thick, sticky mucus that contains blood and bacteria.

Respiratory System Signs and Symptoms

People who have CF have thick, sticky mucus that builds up in their airways. This buildup of mucus makes it easier for bacteria to grow and cause infections. Infections can block the airways and cause frequent coughing that brings up thick sputum (spit) or mucus that’s sometimes bloody.

People who have CF tend to have lung infections caused by unusual germs that don’t respond to standard antibiotics. For example, lung infections caused by bacteria called mucoid Pseudomonas are much more common in people who have CF than in those who don’t. An infection caused by these bacteria may be a sign of CF.

People who have CF have frequent bouts of sinusitis (si-nu-SI-tis), an infection of the sinuses. The sinuses are hollow air spaces around the eyes, nose, and forehead. Frequent bouts of bronchitis (bron-KI-tis) and pneumonia (nu-MO-ne-ah) also can occur. These infections can cause long-term lung damage.

As CF gets worse, you may have more serious problems, such as pneumothorax (noo-mo-THOR-aks) or bronchiectasis (brong-ke-EK-ta-sis).

Some people who have CF also develop nasal polyps (growths in the nose) that may require surgery.

Digestive System Signs and Symptoms

In CF, mucus can block tubes, or ducts, in your pancreas (an organ in your abdomen). These blockages prevent enzymes from reaching your intestines.

As a result, your intestines can’t fully absorb fats and proteins. This can cause ongoing diarrhea or bulky, foul-smelling, greasy stools. Intestinal blockages also may occur, especially in newborns. Too much gas or severe constipation in the intestines may cause stomach pain and discomfort.

A hallmark of CF in children is poor weight gain and growth. These children are unable to get enough nutrients from their food because of the lack of enzymes to help absorb fats and proteins.

As CF gets worse, other problems may occur, such as:

  • Pancreatitis (PAN-kre-ah-TI-tis). This is a condition in which the pancreas become inflamed, which causes pain.
  • Rectal prolapse. Frequent coughing or problems passing stools may cause rectal tissue from inside you to move out of your rectum.
  • Liver disease due to inflamed or blocked bile ducts.
  • Diabetes.
  • Gallstones.

Reproductive System Signs and Symptoms

Men who have CF are infertile because they’re born without a vas deferens. The vas deferens is a tube that delivers sperm from the testes to the penis.

Women who have CF may have a hard time getting pregnant because of mucus blocking the cervix or other CF complications.

Other Signs, Symptoms, and Complications

Other signs and symptoms of CF are related to an upset of the balance of minerals in your blood.

CF causes your sweat to become very salty. As a result, your body loses large amounts of salt when you sweat. This can cause dehydration (a lack of fluid in your body), increased heart rate, fatigue (tiredness), weakness, decreased blood pressure, heat stroke, and, rarely, death.

CF also can cause clubbing and low bone density. Clubbing is the widening and rounding of the tips of your fingers and toes. This sign develops late in CF because your lungs aren’t moving enough oxygen into your bloodstream.

Low bone density also tends to occur late in CF. It can lead to bone-thinning disorders called osteoporosis and osteopenia.

Sonu Gulfam
Sonu Gulfam is a beloved thought leader in the areas of online education, web developing, content writer. He overcame career adversity at an early age by finding his own path and true passion. Despite his success in web developing, Gulfam’s greatest joys are spending time with his family and friends as well as helping inspire and educate others on how to succeed with their own entrepreneurial careers. Since 2016, however, he’s become more interested in areas of web developing, specifically in the world of website design. Sonu is routinely praised for his authentic leadership style and business principles. Countless podcasts and blogs have featured his story and the techniques he uses to manage and grow this audience. Presently, Gulfam enjoys focusing on writing books, growing his top-ranked business website, and learning more about changing education and how kids learn.